Compared to previous studies in rodents, we performed analyses in leptin a (lepa) knockout (KO) zebrafish with novel tank, mirror biting, predator avoidance, social interaction, shoaling, color preference and circadian rhythm tests for multiple behavioral endpoints such as anxiety, new environment exploration, aggressiveness, fear response, social behavior, day/night activity in circadian rhythms and color preference assays. The gene discussed is LEP; the disease is Anxiety.