A recent experimental study reported that both antisense oligonucleotide-mediated knockdown and genetic deletion of the TMAO-producing enzyme FMO3 protected mice against high-fat diet-induced obesity, thus highlighting a role of the gut microbe-driven TMA/FMO3/TMAO pathway in affecting specific transcriptional reprogramming in white adipocytes [11]. The gene discussed is FMO3; the disease is obesity disorder.