The genes related to familial inheritance in ALS (in order of importance) are SOD1, encoding a copper/zinc superoxide dismutase [66,76] whose alteration produces cytotoxicity, mitochondrial dysfunction, oxidative stress, axonal aberrations, and is involved in endosome traffic [79,80,81,82,83,84,85]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.