PRKN and Parkinson disease: Another autosomal dominant mutation is the leucine-rich repeat kinase 2 (LRRK2 or PARK2), located in the pericentromer region of chromosome 12, having reported mutations p.R1441G, p.R1444C, p.Y1699C, p.I1122V, p.I2020T, p.L1114L, and pG2019S; it is responsible for around 2% of sporadic familial PD cases in different countries [141].