The neuroinflammatory reaction caused by neurons and non-neuronal cells in neurodegenerative diseases (NDs) is persistent due to many triggering factors leading to the mutation of genes altering proteins implicated in the development of neurodegeneration such as the beta amyloid protein in AD, the alpha-synuclein protein in PD, and the superoxide dismutase (SOD)-1 mutation in amyotrophic lateral sclerosis (ALS), as discussed later on [3]. The gene discussed is SNCA; the disease is Parkinson disease.