Many targets involved in cancer therapy have also been predicted as potential targets for lignans, such as AP1 endonuclease (position 6 in 753 activity classes), tumor antigen p53 (position 7 in 753 activity classes), GLI family zinc (position 11 in 753 activity classes), RecQ-like DNA helicase 1 (position 14 in 753 activity classes). The gene discussed is GLI1; the disease is cancer.