According to the in silico prediction (position 49 in 753 models), the lignans can act DNA damage-inducible transcript 3 protein (C/EBP homologous protein, CHOP) which has been proposed as a target of treatments for some neurodegenerative diseases as Alzheimer’s diseases [52]. The gene discussed is DDIT3; the disease is early-onset autosomal dominant Alzheimer disease.