Since TET1-CD can induce genome-wide DNA demethylation, it is possible that oncogenes such as C-myc, Bmi1, EMS1, Kpna2 and c-fos in hepatocellular carcinoma epigenetics [28] are also activated so as to weaken TET1-CD anticancer activity. This evidence concerns the gene KPNA2 and hepatocellular carcinoma.