However, a recent study showed that HB‐EGF was upregulated in osteoarthritis cartilage samples and HB‐EGF promoted the catabolic activities of articular chondrocytes.26 Thus, the roles of HB‐EGF signaling in development of the skeleton and the etiology of related diseases remain unclear and need further investigation. The gene discussed is HBEGF; the disease is osteoarthritis.