On the basis of TP53 mutation analysis, 10 cases were interpreted to represent disseminated endometrial serous adenocarcinoma, 5 cases were favored to be primary adnexal/tubal tumors, and 6 cases showed mixed (endometrial and adnexal) origin of the metastatic deposits; “free floating tumor cells” (intraluminal tumor cells) were identified in 5 of the cases. Here, TP53 is linked to endometrial serous adenocarcinoma.