TP53 and neoplasm: Because HPV-related molecular alterations, high-risk HPV-related endocervical adenocarcinomas rarely, if ever, harbor TP53 mutations and thus lack the aberrant (mutation-type) p53 expression patterns seen in serous adenocarcinomas and some other high-grade endometrial carcinomas; rather, high-risk HPV-related endocervical adenocarcinomas almost always exhibit a heterogenous (wild-type) pattern of p53 expression, characterized by scattered weak to moderate nuclear expression in some tumor cells.