TP53 and endometrial carcinoma: These patterns are described in detail in another review in this series (Interpretation of p53 Immunohistochemistry in Endometrial Carcinomas: Towards Increased Reproducibility), and include the most common diffuse strong positive nuclear reaction (overexpression pattern) (Fig. 5D), the less common complete absence of nuclear expression pattern (null-pattern), and the very uncommon cytoplasmic pattern of immunoreactivity.