POLE and endometrial carcinoma: They include the following: POLE mutated/ultramutated; microsatellite instability-high (MSI-H)/hypermutated; copy number low (conceptually similar to “type I” endometrial carcinoma); and copy number high (presence of many genomic amplifications and/or deletions), also known as “the serous-like group,” which is similar to “type II” endometrial carcinoma.