POLE and endometrial cancer: At this time, we do not know if the favorable prognosis of the histologically high-grade POLE-mutant endometrial cancers reflects indolent biology, effective most immunity, or a good response to treatment, and until this is resolved through clinical trials, conventional therapy, based on current risk assessment (eg, European Society of Medical Oncology guidelines), will continue to be implemented for these tumors, and their prognosis will remain excellent.