Consequently, two known mutations, a PSEN1 p.L226R (chr14:73659480) mutation in an EOAD family and a PSEN2 p.H169N (chr1:227075798) in a LOAD family, a novel FTLD gene TANK‐binding kinase 1 (TBK1) p.D534H (chr12:64889341) variant with typical AD phenotype in a LOAD family, and two probably benign MAPTvariants p.Q230R and p.V48L (chr17:44060859 and chr17:44049233) in two sporadic EOAD patients, and some other insignificant variants were identified (online Supporting Information Table S2). The gene discussed is TBK1; the disease is Alzheimer disease.