ASIC1 and disease recurrence: Subsequent studies performed on both acute and chronic EAE models demonstrated that ASIC1 upregulation and function play an important role in the axonal and myelin damage in acute and chronic‐relapsing EAE, while blocking ASIC1 with amiloride exerted a neuro‐ and also myelo‐protective effect in both acute and chronic EAE (Vergo et al., 2011).