Additional interest on ASIC2 was provided by a genetic study on mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS (Jagodic et al., 2004), where strong evidence of linkage in correspondence of the Eae18b QTL was found; in particular, ASIC2 is the closest gene to the peak linkage marker D10Rat123. This evidence concerns the gene ASIC2 and experimental autoimmune encephalomyelitis.