ASIC1 and myeloid sarcoma: The genetic association between rs28936 in the 3′UTR of ASIC2 and MS observed in Nuoro population (Bernardinelli et al., 2007), the evidence that ASIC1 is involved in the pathogenesis of EAE on animal model (Friese et al., 2007) and the altered expression of sodium channels reported in MS (Waxman, 2001) lead us to hypothesize that ASIC2, with which ASIC1 interacts forming heteromultimeric channels, could be an important contributor to neuropathological processes in MS.