Combined with our previous observation that HP1BP3 expression is decreased in cognitively impaired aging humans, the overlap of the broader Hp1bp3 KD transcriptome with that of human aging supports the idea that Hp1bp3 is a critical regulator of a number of the transcriptional changes that occur during aging and may serve as a valuable therapeutic target to delay or prevent aging‐related cognitive decline. This evidence concerns the gene HP1BP3 and Mental deterioration.