Despite the different therapy interval, this is in line with the lower CD4 cell recovery observed in HIV patients with more advanced immunodeficiency.24 Moreover, HHV8 antibodies titres were significantly higher in cART‐treated AIDS‐KS patients compared to asymptomatic subjects (Table S1), a finding consistent with the higher amount of lytic and latent antigens that the immune system encounters in patients with KS tumour compared to tumour‐free subjects. Here, CD4 is linked to Kaposi's sarcoma.