CD40LG and neoplasm: Moreover, they also found that MDP bound to IgM mAbs specific for L1210 leukemic cells (F2‐10‐23‐IgM) and for Lewis lung carcinoma 3LL cells (6B6‐IgM), activated thioglycolate‐elicited mouse peritoneal macrophages, in turn leading to a growth inhibitory effect in target cancer cells.169 Specifically, the coating of L1210 tumor cells with MDP‐F2‐10‐23‐IgM (10 μg/mL MDP bound to 200 μg/mL F2‐10‐23‐IgM) and incubated with macrophages resulted in 80% growth inhibition of L1210 tumor cells whereas comparable concentrations of free MDP resulted only in 5% to 10% tumor growth inhibition.