Besides its anticancer activity, TNF‐α is also involved in the development of the tissue architecture necessary for tumor growth and metastatic dissemination, as well as in the induction of other cytokines, angiogenic factors, and MMPs, thus leading to the increased growth and survival of tumor cells.179 Although 32 exerts its antimetastatic activity through modulation of TME, there is still a lot unknown about the exact mechanism of this modulation. This evidence concerns the gene TNF and neoplasm.