PSMD1 and dementia: 2010a; Mani et al. 2011). Activation of Kv7 channels in pressurized cerebral arteries inhibited myogenic constriction at >20 mmHg, whereas inhibition of the channels enhanced the myogenic response at 20 mmHg (Zhong et al. 2010a). However, there are no studies on the function of Kv7 channels in cerebral arteries from animal models of dementia. Using the Kv7.2‐7.5 activator S‐1 (Bentzen et al. 2006), this study found that Kv7 channel function was attenuated in cerebral arteries of the rTg4510 mice.