No spinal or intracranial meningiomas, which are characteristic of pathogenic loss‐of‐function variants in SMARCE1, were detected in a recent MRI, which showed a dysgenesis and hypoplasia of the corpus callosum and a global dilatation of the ventricular system, characteristic of Coffin–Siris patients. Here, SMARCE1 is linked to intracranial meningioma.