While TWIST1 has been shown to suppress BAX in prostate cancer cell lines (Kwok et al., 2005), further work is warranted to explore whether the upregulation of BAX and BCL‐XL in TWIST1 overexpressed CH1‐ and OV17R‐shFZD7 clones is indeed directly induced by TWIST1. The gene discussed is TWIST1; the disease is Familial prostate cancer.