INS and obesity due to melanocortin 4 receptor deficiency: We identified that alterations to Ly6Chigh monocyte phenotype during obesity are TNF‐dependent, begin in the bone marrow, and lead to a higher prevalence of circulating immature and migration‐primed inflammatory Ly6Chigh monocytes that positively correlate with serum insulin, linking peripheral immune function with endocrine dysregulation.