Increasing evidence indicates that HOTTIP is overexpressed in prostate cancer, lung cancer, and pancreatic cancer.15, 16, 17 HOTTIP knockdown impedes cell viability, proliferation, invasion, and angiogenesis in human cancer cells,18, 19 therefore it is been identified as an oncogenic long noncoding RNA (lncRNA). This evidence concerns the gene HOTTIP and Familial prostate cancer.