Furthermore, studies with mouse Kras‐Tp53‐mutant lung adenocarcinoma cells and human pancreatic cancer cells showed that increased expression of MKK4 decreased invasive behavior in culture and restoring expression of MKK4 in the Kras‐Tp53‐mutant mouse cells reduced their metastasis when injected in mice 40. Here, MAP2K4 is linked to familial pancreatic carcinoma.