Phosphorylation of MYPT1 promotes the binding of MYPT1 to 14–3‐3 proteins and suppresses the phosphatase activity of PP1β leading to an increase in myosin light chain 2 (MLC2) phosphorylation and loss of cell adhesion, which can be a hallmark of metastatic cancer cells 23. The gene discussed is PPP1R12A; the disease is metastatic malignant neoplasm.