The cutoff values for distinguishing the patients with IgG4-RD from the healthy controls were as follows: GDF-15, 666 pg/mL (area under the curve 0.92, sensitivity 77.8%, specificity 100%); CCL2, 389 pg/mL (0.68, 39.7%, 90.2%); TIMP-1, 154 ng/mL (0.78, 77.8%, 69.8%); HA, 65.1 ng/mL (0.85, 61.1%, 93%); PIIINP, 9.0 ng/mL (0.74, 81.9%, 68.3%), and the ELF score, 9.7 (0.85, 79.2%, 78.1%). The gene discussed is TIMP1; the disease is immunoglobulin G4-related sclerosing disease.