In-vivo studies demonstrated that xenograft tumor growth was suppressed more significantly in LK cells with hypermethylation of the Dab2 gene promoter rather than SPC cells with hypomethylation of the Dab2 gene promoter, which indicates that radiosensitivity may be enhanced by X-ray induced de-methylation of the Dab2 gene promoter. Here, DAB2 is linked to neoplasm.