CRP and Thrombocytosis: IL-6 may induce bone marrow leukocytosis and thrombocytosis, stimulate hepatocytes to release C-reactive protein (CRP) and acute-phase markers affecting the erythrocyte sedimentation rate (ESR), activate neutrophils and macrophages, and cause T-helper cells to differentiate into type 17 T-helper (Th17) cells [2].