VIM and neoplasm: The IHC staining to human vimentin on lung section showed the presence of tumor foci in the lungs (Fig. 5d), quantification of the lung areas affected by the metastases showed MS275 reduced lung metastases by 2 fold compared to control (1.9% ± 0.9% for MS275 vs. 3.8% ± 1.5% for control) (Fig. 5e).