The activity of the SIRT3 promotor markedly increased in SiHa cells with PIK3CA E542K and E545K mutations following the downregulation of β-catenin, whereas this increase was not evident in SiHa cells with wild-type PIK3CA, suggesting that β-catenin had a negative impact on the promoter activity of SIRT3 in cervical cancer cells with mutant PIK3CA (Fig. 4d). Here, PIK3CA is linked to cervical carcinoma.