To further verify the association between β-catenin and SIRT3 in glucose metabolism in vivo, we compared the expression of β-catenin, SIRT3, GLUT4, and LDHB in patients with cervical cancers harboring wild-type PIK3CA (n = 20), PIK3CA E542K mutation (n = 20), and PIK3CA E545K mutation (n = 20) by IHC. The gene discussed is LDHB; the disease is cervical cancer.