CCNG2 and gastric cancer: Our findings that cyclin G2 suppressed β-catenin expression and TOP/FOP luciferase activities in gastric cancer cells, as well as in HeLa, HT-29, HEK293 and COS-7 cells (Fig. 4a and c), strongly provide evidence that cyclin G2 acts as a suppressor of Wnt/β-catenin signaling.