PLIN1 and metabolic dysfunction-associated steatotic liver disease: Importantly, rational drug design based on 3D crystallography revealed 4-Nitrophenyl 2,3,4-Tri-O-levulinoyl-Î ± −D-mannopyranoside as an inhibitor for perilipin 1 [85] while perilipin 2 inhibition is considered to be a novel strategy in treating NAFLD and other age-related diseases [86].