This overlap is further highlighted by the fact that both ALS and PP are considered neurodegenerative diseases with prion-like inclusions, i.e., TDP43 in ALS, Tau in corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) and alpha-synuclein in multiple system atrophy (MSA) [17]. The gene discussed is TARDBP; the disease is multiple system atrophy.