One characteristic feature of SLE is the production of elevated levels of autoantibodies, particularly those recognizing double-stranded DNA, due to aberrant autoreactive B cells.7, 10 Although T cell help is important for B cell production of autoantibodies,7, 10 DCs play an important role in B cell development and function by producing B cell-activating factor (BAFF), IL-6, IL-12, and IFN-I.11, 12 Therefore, targeting DC activation and functions can lead to the inhibition of autoantibody production, which in turn alleviates SLE progression. The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.