The only RBM20 missense mutation outside of the RSRSP stretch in familial DCM cases with complete penetrance was mapped to a highly conserved glutamate (E) residue in the E-rich region (Beqqali et al., 2016; van den Hoogenhof et al., 2018; Table 1). Here, RBM20 is linked to familial dilated cardiomyopathy.