First, a functional connection of P36 with EphA2, a host cell receptor involved in hepatocyte susceptibility to infection and formation of the PVM, was proposed following the observation that signaling of EphA2 upon interaction with its natural ligand EphrinA1 was disrupted in the presence of P36 (Kaushansky et al., 2015). The gene discussed is EPHA2; the disease is infection.