IFNG and neoplasm: There are many biomarkers of immunotherapy response including PD-L1, other immune-checkpoint molecules, tumor-infiltrating lymphocytes (TILs), IFN-γ (102–104), mutational burden, neoantigens, microsatellite instability, serum markers, radiographic markers, and the “immunoscore” (105) which evaluates the distribution of TILs in the core and in the invasive margin of tumors.