There are many biomarkers of immunotherapy response including PD-L1, other immune-checkpoint molecules, tumor-infiltrating lymphocytes (TILs), IFN-γ (102–104), mutational burden, neoantigens, microsatellite instability, serum markers, radiographic markers, and the “immunoscore” (105) which evaluates the distribution of TILs in the core and in the invasive margin of tumors. Here, CD274 is linked to neoplasm.