We previously demonstrated increased densities of IL-33 positive and ST2 positive microvessels in adenoma/CRC stroma, suggesting that microvessels are not only the cellular sources of IL-33 and ST2 may also be autocrine or paracrine targets for IL-33/ST2 in regulating angiogenesis in the adenoma/CRC microenvironment (19). Here, IL33 is linked to adenoma.