Huang et al. used an MSN of 100 nm in diameter (short axis) and aspect ratios (ARs) of 1, 2, and 4 to show that longer particles were more easily internalized by A375 human melanoma cells; the longer particles appeared to disrupt the actin fibres more; cell adhesion was also affected, as the longer particles decreased the expression of melanoma cell adhesion molecule (MCAM), as well as decreasing cell adhesion itself. The gene discussed is MCAM; the disease is melanoma.