P2RX7 and lymphoma: We also detected novel focal high level amplifications involving multiple oncogenes of potential relevance to lymphoma pathogenesis including TNFRSF11A, PDGFRA, TMEM119 and P2RX7. TNFRSF11A encodes Receptor Activator of Nuclear Factor κ B (RANK) and ligation of this receptor by RANKL results in NF-κB activation.