Tumor-suppressive mRNAs found to be significantly downregulated following irradiation include Tropomyosin 1 (TPM1), LRR Binding FLII Interacting Protein 1 (LRRFIP1), Tetraspanin 5 (TSPAN5), Signal Transducer And Activator Of Transcription 4 (STAT4), CGG Triplet Repeat Binding Protein 1 (CGGBP1)[45–49]. The gene discussed is STAT4; the disease is neoplasm.