Further, we detected lower MFI of CD80 and CD86 on B10 and CD19+CD24hiCD27hi cells in patients with AP and CD19+CD24hiCD27hi cells from AP patients suppressed the cytokine productions of CD4+ T cells and CD14+ monocytes, but the ability of CD19+CD24hiCD27hi cells to induce Tregs response were impaired. The gene discussed is CD19; the disease is alkaline phosphatase measurement.