Function analyses found CD19+CD24hiCD27hi cells from patients with AP suppressed the release of IFN-γ, TNF-α and IL-17 in CD4+CD25− T cells and the release of TNF-α in CD14+HLA-DR− cells, but were unable to induce Tregs response in CD4+CD25+ T cells efficiently. Here, TNF is linked to alkaline phosphatase measurement.