Notably, in contrast to Pla2g2f−/− mice, Pla2g2e−/− mice do not exhibit psoriasis-related phenotypes [35], implying that these two skin sPLA2s—hair follicular sPLA2-IIE and epidermal sPLA2-IIF—play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s in the coordinated regulation of skin homeostasis and diseases. The gene discussed is PLA2G2F; the disease is psoriasis.