PLA2G2F and psoriasis: Indeed, the skin levels of P-LPE are correlated well with those of sPLA2-IIF expression in several skin disease models, and topical application of P-LPE to Pla2g2f−/− skin in vivo or supplementation of Pla2g2f−/− keratinocytes with P-LPE ex vivo restores the psoriasis-related phenotypes.