MAPT and Alzheimer disease: Various tauopathy mouse models have also been generated,19 with most tau transgenic models harboring tau mutations known to be associated with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP‐17), and not associated with AD.20 The mutations accelerate the self‐aggregation of tau or give rise to an isoform shift from 3‐repeat to 4‐repeat tau.