However, a study by Epling-Burnette et al. demonstrated increased expression of CD244 and decreased expression of activation markers CD28 and CD62L on circulating T cells in myelodysplastic syndrome (MDS) patients, suggesting a link between increased CD244 expression and T cell exhaustion in this segment of the MDS/AML spectrum (55). This evidence concerns the gene CD28 and myelodysplastic syndrome.