IL-12/15/18 pre-activated NK cells produced more IFN-γ upon restimulation with cytokines, K562 cells or primary acute myeloid leukemia (AML) blasts in comparison to control NK cells, which had been pre-activated with an equivalent dose of IL-15 (40, 43) or with low-dose IL-15 (44). Here, IFNG is linked to acute myeloid leukemia.