Dessein et al. in a primary study reported that several SNPs (rs9402373, rs12526196, rs9402373, and rs1256196) that lie close to the Connective Tissue Growth Factor (CTGF) gene are associated with severe hepatic fibrosis in individuals affected by hepatosplenic schistosomiasis (39, 60). The gene discussed is CCN2; the disease is Hepatic fibrosis.