In addition, several studies reported that anti-CD38 mAbs are able to deplete CD38+ immunosuppressive cells, such as myeloid-derived suppressor cells, regulatory T cells and regulatory B cells, leading to an increased anti-tumor activity of immune effector cells (18, 19).Thus, these data provide a rationale for the use of an anti-CD38 antibody-based approach as treatment for MM patients. This evidence concerns the gene CD38 and neoplasm.