Similar results were obtained in IFNγ and TLR4 activated mouse macrophages (137), TLR4 stimulated splenocytes (59, 138), TLR4 activated PBMCs from healthy donors and patients with rheumatoid arthritis (59), as well as, TLR7 engaged macrophages (72). The gene discussed is TLR4; the disease is rheumatoid arthritis.