RT-PCR findings indicated that chromium supplementation significantly upregulated the gene expression of PPAR-γ (p = 0.01), GLUT-1 (p = 0.001) and LDLR (p = 0.01) in PBMCs of patients with PCOS compared with the placebo (Figure 2). The gene discussed is LDLR; the disease is polycystic ovary syndrome.