Master modulators of tumor tissues, such as transcriptional modulators, hormones, cytokines, vitamins, epigenetically active drugs, metronomic low-dose chemotherapy and protein-binding drugs cyclooxygenase-2 (COX-2) inhibitors, IMiDs, arsenic trioxide etc. are aiming at reconditioning tumor tissue into a controlled phenotype, thereby diversifying palliative care, or even inducing continuous complete remission (Table 1; Box 1; Hart et al., 2015). The gene discussed is PTGS2; the disease is neoplasm.