It is simultaneously influenced by genetic factors (variants associated with telomerase RNA component loci near the TERC gene, and other loci identified from genome-wide studies) (Njajou et al., 2010; Armanios and Blackburn, 2012), and non-genetic factors like the environment (smoking, socioeconomic status, physical activity, fatty acid intake, psychological stressors, and various cardiovascular, endocrine, pulmonary, and skin disorders) (Honig et al., 2006; Cherkas et al., 2008; Thomas et al., 2008; Farzaneh-Far et al., 2010; Nawrot et al., 2010; Gu et al., 2011). The gene discussed is TERC; the disease is skin disorder.