In this study, we first compared the expression patterns of exosome circRNAs between HCC patients with higher and lower body fat ratios (BFRs) and found that exosome circ-BD (circular RNA related to deubiquitylation, has_circ_0025129) as well as USP7 are positively related to the BFR. Here, USP7 is linked to hepatocellular carcinoma.