We revealed multiple quasispecies of EBV in individual NKTCL samples, which were reflected by diverse mutations with enrichment in a few hotspots common in different diseases, such as EBNA1, EBNA3, and LMP1 [8, 11], as well as a set of NKTCL-specific mutations/alterations in BPLF1 and EBNA family (Figure S1). This evidence concerns the gene PDLIM7 and extranodal nasal NK/T cell lymphoma.