Similar to previously published studies [5, 29, 30], genes, including STAT3, TP53, DDX3X, and KMT2D were mutated in our NKTCL samples, and recurrent mutations were most frequently found in JAK-STAT pathway, tumor suppressors, epigenetic modifiers, and RAS-MAPK pathway (Figure S3). The gene discussed is DDX3X; the disease is extranodal nasal NK/T cell lymphoma.