Acquired somatic alterations, including DDX3X, TP53, and STAT3 mutations have been determined in NKTCL tumors and the related signaling pathways, such as JAK-STAT, NF-κB, and MAPK pathways have been implicated in its pathogenesis [5, 6]. This evidence concerns the gene TP53 and extranodal nasal NK/T cell lymphoma.