A more recent study of 203 families with at least 2 living relatives with a history of dementia recruited from the same Caribbean Latino communities in the greater New York City area, the Dominican Republic, and Puerto Rico reported a higher apoE4 allele frequency (23.2% in control group and 32.4% in the AD group) and a significant association of that allele with AD risk20. The gene discussed is APOE; the disease is Alzheimer disease.