GLUT-1 and HIF-1α proteins were strongly stained in LoVo tumor tissues compared with HT29 tumor tissues (55.1 ± 2.85 vs. 32.94 ± 7.62 and 29.14 ± 2.63 vs. 23.13 ± 1.43, respectively, P < 0.05) measured by immunohistochemistry and expressed as mean density (Fig. 5D). This evidence concerns the gene HIF1A and neoplasm.